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Raffaella Tonini

Senior Researcher Tenured - Principal Investigator
Neuromodulation of Cortical and Subcortical Circuits
Research center

To adapt to an ever-changing environment and to reach specific goals, the brain needs to learn to choose between different behavioral options. This neuronal processing is influenced by the activity of neuromodulatory systems that can report selective perceptual and motivational information over multiple timescales. Neuromodulators act through specialized receptors localized on anatomically different pathways to shape the activity of neurons as well as the strength and plasticity of their synapses.  However, we have a limited mechanistic understanding of how the temporal coding of neuromodulatory signals affects the interactions between brain regions for perception and reward to implement neuronal computations.

Our aim is to resolve the spatiotemporal dynamic of behaviorally relevant neuromodulatory signals at cellular resolution by using new tools for probing, analyzing, and engineering  micro- and macrocircuits of the brain.  

All Publications
Moroni A., Mercutio C., Rey G., Piermaria P., Leone R., Russo A., Beltrame M., Tonini R., Saponaro A., Thiel G.
An engineered potassium channel for thermogenetics
Biophysical Journal, vol. 123, (no. 3)
Conference Paper Journal
Barile S., Rais C., Nava L., Caltabiano A., Tonini R.
Astrocytic involvement in valence processing within the Dorsal Raphe Nucleus (DRN)
Society for Neuroscience 2024
Abstract Report Conference
Longaretti A., Mangoni D., Paget-Blanc V., Boender A., Pelloux Y., Nava L., Veggi M., Lau P., Tartaglia G. G., Graziani L., Sanges R., Gustincich S., Tonini R.
L1 lncRNAs-FMRP complex at striatal circuits promotes behavioral inflexibility
Gordon Research Conference - Fragile X and Autism Related Disorders
Abstract Report Conference
Barresi G., Tacchino A., Podda J., Pucci D., Pisanello F., Tonoyan T., Boccardo N., De Micheli L., Brichetto G., De Vittorio M., Berdondini L., Tonini R.
NeuroRobotic TWINning: NRTWIN
29 th Annual RIMS Conference
Poster Conference
Nava L., Bontempi L., Burton C., Barile S., Angius G., Tonini R.
Noradrenergic modulation of dopaminergic neurons in the dorsal raphe nucleus contributes to stress-induced anhedonia
Society for Neuroscience 2024
Abstract Report Conference