Miguel Soler was awarded an ARDF grant!
Alternatives Research & Development Foundation (ARDF), which supports the development of alternative, non-animal methods in science, has awarded the Group of Sara Fortuna in Trieste university and Dr. Miguel Soler at the CONCEPT Lab with a grant for the project called "In silico design of customised high-affinity antibody fragments".
In this project, we aim to show that our developed computational protocols of binder design can compete and reduce or even avoid the demand for in vivo procedures for antibody discovery and maturation. We will develop high affinity antibody fragments for the molecular recognition of difficult immuno-targets, such as the isoform of the cancer biomarker HER2. This approach will advance over the current state-of-the-art techniques, being (i) more cost-effective; and (ii) capable of overcoming the difficulties in the selection of a specific binding site.